Research on the Particle Breakage Mechanism in High-Speed Shear Wet Granulation

on the status of mixed methods research in applied linguistics

چکیده ندارد.

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

A PAT approach to improve process understanding of high shear wet granulation through in-line particle measurement using FBRM C35.

This article summarizes the investigation of in-line particle characterization during high shear wet granulation (HSWG) using focused beam reflectance measurement (FBRM) for enhanced process understanding, which is part of an effort to develop this drug product within the framework of quality by design (QbD) and process analytical technology (PAT). Traditionally, the effectiveness of in-line mo...

Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer

dilation and particle breakage effects on the shear strength of calcareous sands based on energy aspects

in this paper shear behavior of two calcareous sands having different physical properties areinvestigated using drained and undrained triaxial tests. the investigated sands are obtained from two differentzones located in persian gulf, kish island and tonbak region. analysis based on energy aspects show thatfriction angle in these soils, having crushable particles, is formed of three components:...